Shasha Zhang
Associate Professor, Ph.D. Supervisor
Email：zhangshasha@seu.edu.cn
Office：Advanced Institute for Life and Health (Science and Technology Industrial Park of Southeast University, Qixia District)
Personal Profile:
Shasha Zhang, an associate Professor, Ph.D. Supervisor at the School of Life Sciences and Technology, Southeast University, mainly engaged in research on regeneration and protection of inner ear hair cells, as well as targeted delivery into the inner ear. Both undergraduate and doctoral degrees were obtained from Tsinghua University, under the guidance of Academician Prof. Peng Li. Currently serving as the Deputy Director of Research for Department of Otolaryngology Head and Neck Surgery at Zhongda Hospital, Vice Chairman of the Hearing Professional Committee of Jiangsu Developmental Biology Society, and Youth Editorial Board Member of Sensory Neuroscience Journal. The research results have been published over 40 research papers in internationally influential academic journals such as Advanced Science and Biomaterials. Applied for or authorized more than ten patents, and published a monograph as the deputy editor in chief. Selected for talent projects such as Jiangsu Province 333 High Level Talents, Jiangsu Province Excellent Youth, and Jiangsu Province Youth Support Program. Hosted more than ten national and provincial-level scientific research projects, including the National Key R&D Program of China and the National Natural Science Foundation of China. Received academic awards such as the Chinese Medical Science and Technology Award for Medical Science and Technology, Jiangsu Provincial Science and Technology Award, and Huaxia Medical Science and Technology Award.
Research Direction:
1. Utilize inner ear stem cells to regenerate functional hair cells, repair damaged inner ear structures, and reconstruct auditory function
2. Engineering construction of targeted delivery vehicles for the inner ear
Recent representative papers:
(# co-first author; * corresponding author)
H. Xiao#, J. Wu#, L. Huang#, Y. Ma#, L. Wu#, Y. Lin, Z. Ye, X. Tan, X. Tang, W. Tong, M. Dai, Y. Wang, X. Sheng, R. Chai*, S. Zhang*. Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea. Advanced Science. 2025 May; 12(18):e2412653.
P. Jiang#, X. Ma#, X. Wang#, J. Huang, Y. Wang, J. Ai, H. Xiao, M. Dai, Y. Lin, B. Shao, X. Tang, W. Tong, Z. Ye, R. Chai*, and S. Zhang*. Isolation and Comprehensive Analysis of Cochlear Tissue-derived Small Extracellular Vesicles. Advanced Science. 2024 Dec; 11(48):e2408964.
J. Ai#, S. Zhang#*, M. Dai, P. Jiang, J. Huang, H. Xiao, Y. Lin, X. Tang, W. Tong, J. He, Q. Mao, Y. Wang, Z. Ye, T. Wang*, R. Chai*. Small Extracellular Vesicles Orchestrate Cisplatin-Induced Ototoxicity: Potential Biomarker and Targets Discovery. Advanced Science. 2025 May 24:e02627.
Y. Lin, Q. Zhang, W. Tong, Y. Wang, L. Wu, H. Xiao, X. Tang, M. Dai, Z. Ye, R. Chai, S. Zhang*. Conditional overexpression of Net1 enhances the trans-differentiation of Lgr5+ progenitors into hair cells in the neonatal mouse cochlea. Cell Proliferation. 2025 Apr; 58(4):e13787.
X. Wang#, H. Xiao#, J. Wu#, Y. Lin#, Y. Ao#, Z. Ye, X. Tan, F. Kong, X. Chen*, R. Chai*, S. Zhang*. Single-nucleus transcriptomics uncovers Xaf1-driven PANoptosis as a therapeutic target in aminoglycoside-induced hearing loss. Cell Proliferation. 2025 Jul; 2:e70081.
P. Jiang#, X. Ma#, S. Han#, L. Ma#, J. Ai, L. Wu, Y. Zhang, H. Xiao, M. Tian, W. Tao*, S. Zhang*, R. Chai*. Characterization of the microRNA transcriptomes and proteomics of cochlear tissue-derived small extracellular vesicles from mice of different ages after birth. Cellular and Molecular Life Sciences, 2022. 79(3): p. 154.
S. Zhang#, Y. Zhang, L. Guo, Z. Zhang, Y. Dong, B. Shao, J. Qi, H. Zhou, W. Zhu, X. Yan, G. Hong, L. Zhang, X. Zhang, M. Tang, C. Zhao, X. Gao, R. Chai*. Knock-down of Foxg1 in Supporting Cells Increases the Transdifferentiation of Supporting Cells into Hair Cells in the Neonatal Mouse Cochlea. Cellular and Molecular Life Sciences, 77(7): 1401-1419, 2020