姓名:刘安
职称:副研究员
办公室/实验室:太阳成集团江北校区汇川楼A405/A401
邮箱:liu_an@seu.edu.cn
教育和工作简历:
2006.09-2010.06 太阳成集团生物工程专业,本科
2010.09-2016.06 太阳成集团生命科学研究院生物学专业,博士
2016.06-2018.11 太阳成集团生命科学研究院,博士后
2021.09-2022.09 多伦多大学附属病童医院,访问学者
2019.3至今suncitygroup太阳集团 副研究员
研究领域:
1.学习记忆机制;
2.精神疾病发病机理及干预。
代表性论文
1.Yan L#, Zhang X#, Jin L, Li Y, Chen Y, Zhang J, Sun Z, Qi J, Qu C, Dong G, Zhang Y, Jiang Q*, Liu A*, Li J*. The ARCCRABP1 neurons play a crucial role in the regulation of energy homeostasis. Nat Commun. 2025 Mar 8;16(1):2319.
2.Lv D#, Liu A#*, Yi Z, Mu M, Wu M, Li X, Cao K, Liu R, Jia Z, Han J, Xie W*. Neuroligin 1 Regulates Autistic-Like Repetitive Behavior through Modulating the Activity of Striatal D2 Receptor-Expressing Medium Spiny Neurons. Adv Sci (Weinh). 2025 Feb;12(5):e2410728.
3.Dang R#, Liu A#*, Zhou Y, Li X, Wu M, Cao K, Meng Y, Zhang H, Gan G, Xie W*, Jia Z*. Astrocytic neuroligin 3 regulates social memory and synaptic plasticity through adenosine signaling in male mice. Nat Commun. 2024 Oct 5;15(1):8639.
4.Ren Q#, Wang S#, Li J, Cao K, Zhuang M, Wu M, Geng J, Jia Z, Xie W, Liu A*. Novel Social Stimulation Ameliorates Memory Deficit in Alzheimer's Disease Model through Activating α-Secretase. J Neurosci. 2024 Mar 20;44(12):e1689232024.
5.Dang R#, Zhou Y#, Zhang Y, Liu D, Wu M, Liu A*, Jia Z*, Xie W*. Regulation of Social Memory by Lateral Entorhinal Cortical Projection to Dorsal Hippocampal CA2. Neurosci Bull. 2022 Mar;38(3):318-322.
6.Liu A, Ji H, Ren Q, Meng Y, Zhang H, Collingride G, Xie W*, Jia Z*. The Requirement of the C-Terminal Domain of GluA1 in Different Forms of Long-Term Potentiation in the Hippocampus Is Age-Dependent. Front Synaptic Neurosci. 2020 Oct 30;12:588785.
7.Liu A#, Zhang Y#, Han L, He G, Xie W, Zhou Z, Jia Z*. Regulation of Neurotransmitter Release by Amyloid Precursor Protein Through Synapsin Phosphorylation. Neurochem Res. 2019 Mar;44(3):683-691.
8.Zhou Z#, Liu A#, Xia S#, Leung C#, Qi J, Meng Y, Xie W, Park P, Collingridge GL*, Jia Z*. The C-terminal tails of endogenous GluA1 and GluA2 differentially contribute to hippocampal synaptic plasticity and learning. Nat Neurosci. 2018 Jan;21(1):50-62.
9.Dang R#, Qi J#, Liu A#, Ren Q, Lv D, Han L, Zhou Z, Cao F, Xie W*, Jia Z*. Regulation of hippocampal long term depression by Neuroligin 1. Neuropharmacology. 2018 Dec;143:205-216.
10.Liu A#, Zhou Z#, Dang R, Zhu Y, Qi J, He G, Leung C, Pak D, Jia Z*, Xie W*. Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization. J Cell Biol. 2016 Feb 15;212(4):449-63
主持及参与项目
(1)国家自然科学基金委员会面上项目, 32571220, 腹侧海马区蛋白剪切参与社交记忆形成和维持的机制研究,2026-01-01 至 2029-12-31, 50万元, 主持。
(2)科技部重大研究计划, 2021ZD0204000, 社交行为的神经环路机制解析及社交障碍的干预研究, 2021-12 至 2026-11, 280/4000万元, 在研, 课题骨干;
(3)科技部重大研究计划, 2022ZD0205900, 谷氨酸能突触形成与可塑性的分子构架解析, 2022-8 至 2027-7, 150/500万元, 在研, 课题骨干;
(4)江苏省科技厅优秀青年项目, BK20211561, NLG1调控自闭症行为的机制研究, 2021-07 至 2024-06, 50万元, 结题, 主持;
(5)国家自然科学基金委员会面上项目, 31970958, 树突棘和AMPAR活动在社交记忆印迹细胞形成过程中的功能研究, 2020-01-01 至 2023-12-31, 58万元, 结题, 主持。
(6)中国博士后创新人才计划,2016年。