张莎莎 副研究员、博士生导师
Email：zhangshasha@seu.edu.cn
办公地点：生命健康高等研究院（太阳成集团科技产业园（栖霞区））
个人简介：
张莎莎，suncitygroup太阳集团副研究员、博士生导师，主要从事内耳毛细胞再生和保护、内耳靶向递送等方面的研究。本科和博士均毕业于清华大学，师从李蓬院士。现兼任中大医院耳鼻喉头颈外科科研副主任、江苏省发育生物学会听觉专业委员会副主任委员、Sensory Neuroscience杂志青年编委等学术兼职。研究成果已发表在Advanced Science、Biomaterials等有国际影响力的学术期刊四十余篇。申报及授权专利十余项，作为副主编出版专著一部。先后入选江苏省333高层次人才、江苏省优青、江苏省青托等人才项目，先后主持国家重点研发计划课题、国家自然科学基金等十余项国家级和省部级科研项目。获得中华医学科技奖医学科学技术奖、江苏省科学技术奖、华夏医学科学技术奖等学术奖励。
研究方向：
1.利用内耳干细胞再生功能性毛细胞，修复损伤的内耳结构、重建听觉功能
2.内耳靶向递送载体的工程化构建
近期代表性论文：
(# co-first author; * corresponding author)
H. Xiao#, J. Wu#, L. Huang#, Y. Ma#, L. Wu#, Y. Lin, Z. Ye, X. Tan, X. Tang, W. Tong, M. Dai, Y. Wang, X. Sheng, R. Chai*, S. Zhang*. Conditional Overexpression of Serpine2 Promotes Hair Cell Regeneration from Lgr5+ Progenitors in the Neonatal Mouse Cochlea. Advanced Science. 2025 May; 12(18):e2412653.
P. Jiang#, X. Ma#, X. Wang#, J. Huang, Y. Wang, J. Ai, H. Xiao, M. Dai, Y. Lin, B. Shao, X. Tang, W. Tong, Z. Ye, R. Chai*, and S. Zhang*. Isolation and Comprehensive Analysis of Cochlear Tissue-derived Small Extracellular Vesicles. Advanced Science. 2024 Dec; 11(48):e2408964.
J. Ai#, S. Zhang#*, M. Dai, P. Jiang, J. Huang, H. Xiao, Y. Lin, X. Tang, W. Tong, J. He, Q. Mao, Y. Wang, Z. Ye, T. Wang*, R. Chai*. Small Extracellular Vesicles Orchestrate Cisplatin-Induced Ototoxicity: Potential Biomarker and Targets Discovery. Advanced Science. 2025 May 24:e02627.
Y. Lin, Q. Zhang, W. Tong, Y. Wang, L. Wu, H. Xiao, X. Tang, M. Dai, Z. Ye, R. Chai, S. Zhang*. Conditional overexpression of Net1 enhances the trans-differentiation of Lgr5+ progenitors into hair cells in the neonatal mouse cochlea. Cell Proliferation. 2025 Apr; 58(4):e13787.
X. Wang#, H. Xiao#, J. Wu#, Y. Lin#, Y. Ao#, Z. Ye, X. Tan, F. Kong, X. Chen*, R. Chai*, S. Zhang*. Single-nucleus transcriptomics uncovers Xaf1-driven PANoptosis as a therapeutic target in aminoglycoside-induced hearing loss. Cell Proliferation. 2025 Jul; 2:e70081.
P. Jiang#, X. Ma#, S. Han#, L. Ma#, J. Ai, L. Wu, Y. Zhang, H. Xiao, M. Tian, W. Tao*, S. Zhang*, R. Chai*. Characterization of the microRNA transcriptomes and proteomics of cochlear tissue-derived small extracellular vesicles from mice of different ages after birth. Cellular and Molecular Life Sciences, 2022. 79(3): p. 154.
S. Zhang#, Y. Zhang, L. Guo, Z. Zhang, Y. Dong, B. Shao, J. Qi, H. Zhou, W. Zhu, X. Yan, G. Hong, L. Zhang, X. Zhang, M. Tang, C. Zhao, X. Gao, R. Chai*. Knock-down of Foxg1 in Supporting Cells Increases the Transdifferentiation of Supporting Cells into Hair Cells in the Neonatal Mouse Cochlea. Cellular and Molecular Life Sciences, 77(7): 1401-1419, 2020
